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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Vitamin k

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Vitamin k

Non-vitamin K oral anticoagulants (NOACs); Vitamin K antago 2 The Cochrane Heart Group 2 Severe COVID-19. Vitamin K treatment. 1 Atrial fibrillation, diabetes mellitus 1 Vascular calcification in chronic kidney diseases. 1 Vitamin K Deficiency 1 The use of non-vitamin K antagonist oral anticoagulants vs. 1 Endocrinology, Bone health. Osteoporosis, the most common bo 1 Rheumatoid arthritis. 1 Atrial Fibrillation Patients taking Non-vitamin K Antagonist 1 Up to 80% of patients with mitral stenosis and systemic embo 1 Non-vitamin K Antagonist Oral Anticoagulants for Cancer Asso 1

📋 Sample Trials

NCT05360342

Incorporation of Vitamin K Into Uremic Lipoproteins

Completed

NCT05742295

Prevention of Cefoperazone-induced Coagulopathy

Completed · Phase 4

📊 Sample Meta-Analyses

CRD42017060344

A systematic review and meta-analysis of the effect of vitamin K supplementation on vascular health

Vitamin K is necessary for correct function of enzymes involved in bone metaboli

CRD42018087492

Does oral vitamin K supplementation reduce bone loss and prevent fractures in adults? An update

Fractures and bone density changes in adults.

CRD42021251825

The combined efect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials

Endocrinology, Bone health. Osteoporosis, the most common bone disease character

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Vitamin k

⚗️ Identity

Name

Vitamin k

Aliases / Synonyms

12001-79-5; 81818-54-4; Kephton; 2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione; Vitamin K1(20); .alpha.-Phylloquinone; 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione; 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione; (E)-2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione

🧪 Chemistry

Molecular Weight

450.7070

LogP

9.1576

Drug-likeness

0.265

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C

Isomeric SMILES

CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCCC(C)CCCC(C)CCCC(C)C

InChIKey

MBWXNTAXLNYFJB-LKUDQCMESA-N

InChI

InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+

🔗 External References

HERB DB

HBIN048067 ↗

PubChem CID

5280483 ↗

DrugBank

DB01022 ↗

NPASS

NPC1682

SymMap

18325

TCMID

23288

TCM-ID

9858

🔍 Raw view — every non-empty column on this row (31 fields)

name

Vitamin k

common names

herb ingredient id

HBIN048067

canonical smiles

CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C

isomeric smiles

CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCCC(C)CCCC(C)CCCC(C)C

inchi

InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+

inchikey

MBWXNTAXLNYFJB-LKUDQCMESA-N

mol wt

450.7070

num h acceptors

num h donors

mol logp

9.1576

num rotatable bonds

drug likeness

0.265

symmap mol id

18325

tcmid ingredient id

23288

tcm id ingredient id

9858

pubchem cid

5280483

drugbank id

DB01022

npass id

NPC1682

🏥 Linked Health Topics

1 · diseases via target pathways

Vitamin K Deficiency

syndrome

📋 Clinical Trials

2 · subject of clinical study

NCT05360342 Incorporation of Vitamin K Into Uremic Lipoproteins

→ Vitamin K Deficiency

NCT05742295 Prevention of Cefoperazone-induced Coagulopathy

→ Antibiotic Side Effect

📊 Meta-Analyses

12 · systematic review

CRD42017060344 A systematic review and meta-analysis of the effect of vitamin K supplementation

→ Vitamin K is necessary for correct function of enz

CRD42018087492 Does oral vitamin K supplementation reduce bone loss and prevent fractures in ad

→ Fractures and bone density changes in adults.

CRD42021251825 The combined efect of vitamin K and calcium on bone mineral density in humans: a

→ Endocrinology, Bone health. Osteoporosis, the most

CRD42022300362 Impact of Different Forms of Vitamin K, Calcium, Vitamin D, or Their Combination

→ Osteoporosis.

CRD42017078915 Non-vitamin K oral anticoagulants in patients with atrial fibrillation: an overv

→ Anticoagulant therapy in patients with atrial fibr

CRD42020159237 Non-vitamin K antagonist oral anticoagulants versus warfarin for the secondary s

→ Atrial fibrillation. Ischemic stroke. Secondary pr

CRD42018099851 The safety and efficacy of vitamin K antagonists in women compared to those in m

→ Non-valvular atrial fibrillation.

CRD42018110497 Efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs) in e

CRD42019118812 Anticoagulation control in patients on vitamin K antagonists in Africa: a system

→ Anticoagulation control in patients on vitamin K a

CRD42016038485 The impact of additional vitamin K, post antibiotic use, in patients with kidney

→ Renal disease

CRD42020197361 Systematic review analysis to review the efficacy of warfarin reversal with vita

→ Neck of femur / Hip fracture patients are elderly

CRD42020178771 Non-vitamin K antagonist oral anticoagulants versus warfarin for prevention of s

→ Stroke and bleeding in patients with atrial fibril

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables