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Ingredient
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Gene Target
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Disease
30,467
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
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⚗️ Ingredient

Trans-caffeic acid

Open on HERB 2.0 ↗
4
Clinical Trials
3
Meta-Analyses
5
PubMed References
Top Conditions Studied with Trans-caffeic acid
Immune Thrombocytopenia 2 Esophagus Cancer, Stage III 1 Esophagus Cancer 1 Thrombocytopenias 1 The main ingredient of caffeic acid tablet is caffeic acid, 1
📋 Sample Trials
NCT02556814
Caffeic Acid Combining High-dose Dexamethasone in Management of ITP
Completed · Phase 4
NCT04648917
GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC)
Unknown · Phase 3
NCT02351622
Caffeic Acid Tablets as a Second-line Therapy for ITP
Completed · Phase 3
📊 Sample Meta-Analyses
CRD42021215920
Caffeic acid and its derivatives potential therapeutics effects on different melanoma cell lines: a project to a sistematic review
CRD42023408316
Efficacy and safety of caffeic acid tablets in the treatment of leukopenia: a systematic review and meta-analysis
The main ingredient of caffeic acid tablet is caffeic acid, also known as "3, 4-
CRD42023408324
Efficacy and safety of caffeic acid tablets in the treatment of thrombocytopenia: a systematic review and meta-analysis
Thrombocytopenias
📚 Sample References
PMID 33432954
Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models
Food Funct · 2021
PMID 33562019
Caffeic Acid Enhances the Anti-Leukemic Effect of Imatinib on Chronic Myeloid Leukemia Cells and Triggers Apoptosis in Cells Sensitive and Resistant to Imatinib
Int J Mol Sci · 2021
PMID 33567596
Caffeic Acid Modulates Processes Associated with Intestinal Inflammation
Nutrients · 2021
⚗️ All Ingredient data fields for Trans-caffeic acid
⚗️ Identity
Name
Trans-caffeic acid
Aliases / Synonyms
caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 501-16-6; 3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; (E)-3-(3,4-dihydroxyphenyl)acrylic acid
🧪 Chemistry
Molecular Weight
180.1590
LogP
1.1956
Drug-likeness
0.472
H-Bond Acceptors
3
H-Bond Donors
3
Rotatable Bonds
2
🔬 Structures
Canonical SMILES
C1=CC(=C(C=C1C=CC(=O)O)O)O
Isomeric SMILES
C1=CC(=C(C=C1/C=C/C(=O)O)O)O
InChIKey
QAIPRVGONGVQAS-DUXPYHPUSA-N
InChI
InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+
🔗 External References
HERB DB
HBIN046726 ↗
PubChem CID
689043 ↗
NPASS
NPC294902
HIT
C1203
TCMID
33971; 34443; 32303
🔍 Raw view — every non-empty column on this row (29 fields)
name
Trans-caffeic acid
common names
caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 501-16-6; 3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; (E)-3-(3,4-dihydroxyphenyl)acrylic acid
herb ingredient id
HBIN046726
canonical smiles
C1=CC(=C(C=C1C=CC(=O)O)O)O
isomeric smiles
C1=CC(=C(C=C1/C=C/C(=O)O)O)O
inchi
InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+
inchikey
QAIPRVGONGVQAS-DUXPYHPUSA-N
mol wt
180.1590
num h acceptors
3
num h donors
3
mol logp
1.1956
num rotatable bonds
2
drug likeness
0.472
tcmid ingredient id
33971; 34443; 32303
pubchem cid
689043
npass id
NPC294902
hit id
C1203

📋 Clinical Trials

4 · subject of clinical study
NCT02556814 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP
→ Immune Thrombocytopenia
NCT04648917 GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC)
→ Esophagus Cancer, Stage III
NCT02351622 Caffeic Acid Tablets as a Second-line Therapy for ITP
→ Immune Thrombocytopenia
NCT03070262 The Efficacy and Safety of Caffeic Acid for Esophageal Cancer
→ Esophagus Cancer

📊 Meta-Analyses

3 · systematic review
CRD42021215920 Caffeic acid and its derivatives potential therapeutics effects on different mel
CRD42023408316 Efficacy and safety of caffeic acid tablets in the treatment of leukopenia: a sy
→ The main ingredient of caffeic acid tablet is caff
CRD42023408324 Efficacy and safety of caffeic acid tablets in the treatment of thrombocytopenia
→ Thrombocytopenias

📚 PubMed References

5 · cited research
PMID 33432954 Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditi
Food Funct
PMID 33562019 Caffeic Acid Enhances the Anti-Leukemic Effect of Imatinib on Chronic Myeloid Le
Int J Mol Sci
PMID 33567596 Caffeic Acid Modulates Processes Associated with Intestinal Inflammation
Nutrients
PMID 33785337 Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi
Life Sci
PMID 36191632 The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia induci
Eur J Pharmacol
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables