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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Quercetin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

100

PubMed References

Top Conditions Studied with Quercetin

Covid-19 5 Aging 2 Covid19 2 Chronic Obstructive Pulmonary Disease 2 Endometriosis 1 oxidative stress 1 Sarcoidosis 1 Diabetes Mellitus, Type 2 1 On August 24, 2021, the Lancet released the first comprehens 1 Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Sta 1 Pharmacokinetics 1 This review will examine the analgesic effects of quercetin 1

📋 Sample Trials

NCT01912820

Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery

Completed · Phase 1

NCT05008003

Vit D3 for Early Symptoms of COVID-19

Unknown

NCT01691404

Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Function and Blood Pressure (FLAVO)

Completed

📊 Sample Meta-Analyses

CRD42021273276

Quercetin as a potential therapeutic and prophylactic agent for COVID-19: a systematic review of clinical evidence

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a high

CRD42021239852

systematic evaluation and meta-analysis of quercetin against hepatic fibrosis in animal models

CRD42022374228

Clinical outcomes of quercetin for COVID-19 patients: systematic literature review and meta-analysis

In previous studies, quercetin has been shown to have anti-inflammatory and anti

📚 Sample References

PMID 31497913

Quercetin protects against cisplatin-induced acute kidney injury by inhibiting Mincle/Syk/NF-κB signaling maintained macrophage inflammation

Phytother Res · 2020

PMID 31672514

Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctivitis

Food Chem Toxicol · 2020

PMID 31804760

Quercetin alleviates lipopolysaccharide-induced inflammatory responses by up-regulation miR-124 in human renal tubular epithelial cell line HK-2

Biofactors · 2020

⚗️ All Ingredient data fields for Quercetin

⚗️ Identity

Name

Quercetin

Aliases / Synonyms

117-39-5; Sophoretin; Meletin; Quercetine; Xanthaurine; Quercetol; Quertine; Quercitin; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one

🧪 Chemistry

Molecular Weight

302.2380

LogP

1.9880

Drug-likeness

0.434

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

Isomeric SMILES

C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

InChIKey

REFJWTPEDVJJIY-UHFFFAOYSA-N

InChI

InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

🔗 External References

HERB DB

HBIN041495 ↗

PubChem CID

5280343 ↗

CAS Number

117-39-5 ↗

NPASS

NPC20791

HIT

C0352

SymMap

TCMID

18302

TCMSP

MOL000098

TCM-ID

1425

🔍 Raw view — every non-empty column on this row (35 fields)

name

Quercetin

common names

117-39-5; Sophoretin; Meletin; Quercetine; Xanthaurine; Quercetol; Quertine; Quercitin; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one

herb ingredient id

HBIN041495

canonical smiles

C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

isomeric smiles

C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

inchi

InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

inchikey

REFJWTPEDVJJIY-UHFFFAOYSA-N

mol wt

302.2380

num h acceptors

num h donors

mol logp

1.9880

num rotatable bonds

drug likeness

0.434

cas id

117-39-5

symmap mol id

tcmid ingredient id

18302

tcmsp ingredient id

MOL000098

tcm id ingredient id

1425

pubchem cid

5280343

npass id

NPC20791

hit id

C0352

tcmsp mol id

MOL000098

tcmsp molecule id

🌿 Related Herbs

1 · contains this compound

Ephedra

Ma Huang

🧬 Gene / Protein Targets

30 · directly binds these targets

AHR

Gene AHR

ALOX5

Gene ALOX5

Gene AR

CD40LG

Gene CD40LG

CRP

Gene CRP

CTSD

Gene CTSD

EGFR

Gene EGFR

Gene F7

GSTM1

Gene GSTM1

GSTM2

Gene GSTM2

HAS2

Gene HAS2

HMOX1

Gene HMOX1

ICAM1

Gene ICAM1

IFNG

Gene IFNG

INSR

Gene INSR

IRF1

Gene IRF1

EIF6

Gene EIF6

KCNH2

Gene KCNH2

MPO

Gene MPO

PPARG

Gene PPARG

MAPK1

Gene MAPK1

THBD

Gene THBD

TNF

Gene TNF

VEGFA

Gene VEGFA

NR1I2

Gene NR1I2

NR1I3

Gene NR1I3

NCOA2

Gene NCOA2

DUOX2

Gene DUOX2

Prostaglandin G/H synthase 1

Prostaglandin G/H synthase 2

🏥 Linked Health Topics

30 · diseases via target pathways

Sjogren-Larsson Syndrome

Gastrointestinal Cancers

Adult respiratory distress syndrome

disease

Inflammatory lung disease

disease

Inflammatory Bowel Disease

disease

Allergic diseases

disease

Allergic rhinitis, unspecified

disease

Antigen-induced decrease in coronary flow and cardiac anaphylaxis

disease

Bronchiolar carcinoma

disease

Chronic myeloid leukemia

disease

Dermatological disorders

disease

Magnesium deficiency dermatitis

disease

Polyarthritis, unspecified

Hypospadias 1, X-Linked

syndrome

Prostate cancer

disease

Spinal and bulbar muscular atrophy

disease

XY disorders of sex development (Other)

disease

📋 Clinical Trials

12 · subject of clinical study

NCT01912820 Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patie

→ Adenocarcinoma of the Prostate|Recurrent Prostate

NCT05008003 Vit D3 for Early Symptoms of COVID-19

→ Covid19

NCT01691404 Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Fu

→ Hypertension|Endothelial Dysfunction

NCT04468139 The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the C

→ Covid-19

NCT00065676 Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity

→ Obesity|Diabetes

NCT00402623 The Effect of Quercetin in Sarcoidosis

→ Sarcoidosis

NCT01168739 Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body S

→ Heat Acclimation and Thermotolerance

NCT01376011 Modulation of Cerebral Blood Flow Using Quercetin, a Nutritional Supplement

→ Stroke|Problem of Aging

NCT01708278 Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD)

→ Chronic Obstructive Pulmonary Disease

NCT01720147 Quercetin in Children With Fanconi Anemia; a Pilot Study

→ Fanconi Anemia

NCT01722669 Quercetin PK/PD Study in Healthy Adults and Patients With Hypercoagulable States

→ Healthy

NCT01732393 Effect of Quercetin in Prevention and Treatment of Oral Mucositis

→ Chemotherapy Induced Oral Mucositis

📊 Meta-Analyses

12 · systematic review

CRD42021273276 Quercetin as a potential therapeutic and prophylactic agent for COVID-19: a syst

→ The novel severe acute respiratory syndrome corona

CRD42021239852 systematic evaluation and meta-analysis of quercetin against hepatic fibrosis in

CRD42022374228 Clinical outcomes of quercetin for COVID-19 patients: systematic literature revi

→ In previous studies, quercetin has been shown to h

CRD42022383491 Mechanism of action of quercetin in rheumatoid arthritis models: Meta-analysis a

CRD42023389949 The effect of quercetin supplementation on cardiometabolic outcomes: an umbrella

→ Effect of quercetin intervention on lipid profile,

CRD42023391219 Effects of quercetin on outcomes of covid-19 patients: a systematic review and m

→ COVID-19

CRD42016043047 Effect of quercetin supplementation on inflammatory marker C-reactive protein: a

→ C-reactive protein (CRP) is one of the most common

CRD42018086787 Effectiveness of quercetin for rheumatoid arthritis patients

→ Rheumatoid arthritis.

CRD42018088477 Effectiveness of quercetin for hypertensive adults and (pre)hypertensive adults

→ Quercetin Quercetin for hypertensive adults and (

CRD42018094337 The effect of quercetin on muscle atrophy and immune function in adults: a syste

→ Muscular atrophy and immune function.

CRD42020204593 Quercetin supplementation: effects on histomorphometric and metabolic parameters

CRD42020219056 systematic review and meta-analysis of the effect of Quercetin supplementation o

→ oxidative stress

📚 PubMed References

12 · cited research

PMID 31497913 Quercetin protects against cisplatin-induced acute kidney injury by inhibiting M

Phytother Res

PMID 31672514 Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctiviti

Food Chem Toxicol

PMID 31804760 Quercetin alleviates lipopolysaccharide-induced inflammatory responses by up-reg

Biofactors

PMID 32000299 Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db

J Cell Mol Med

PMID 32009956 Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating

Front Pharmacol

PMID 32357395 Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impa

Pharmaceutics

PMID 32363357 The effect of quercetin on endothelial cells is modified by heterocellular inter

Food Funct

PMID 32366711 Quercetin Blocks Ebola Virus Infection by Counteracting the VP24 Interferon-Inhi

Antimicrob Agents Chemother

PMID 32390844 Quercetin Combined With Human Umbilical Cord Mesenchymal Stem Cells Regulated Tu

Front Pharmacol

PMID 32410992 Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothe

Front Pharmacol

PMID 32431618 Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Str

Front Pharmacol

PMID 32599520 Quercetin protects against cerebral ischemia/reperfusion and oxygen glucose depr

J Nutr Biochem

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables