Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Luteolin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Luteolin

Metabolic Syndrome 1 Autism Spectrum Disorders 1 Symptom management in patients with ASD 1 Schizophrenia|Schizoaffective Disorder 1

📋 Sample Trials

NCT03444558

Effects of Natural Supplement Containing Chlorogenic Acid and Luteolin on Cardio-metabolic Risk Factors

Completed

NCT01847521

Effects of the Anti-inflammatory Flavonoid Luteolin on Behavior in Children With Autism Spectrum Disorders

Completed · Phase 2

NCT05204407

Luteolin for the Treatment of People With Schizophrenia

Recruiting

📊 Sample Meta-Analyses

CRD42021226773

Cardioprotective effects and Possible mechanisms of Luteolin for Myocardial ischemia-reperfusion injury: A Systematic Review and Meta-analysis

CRD42023490581

Efficacy of antioxidant-based pharmacological therapies in Autism Spectrum Disorder: A Systematic Review

Symptom management in patients with ASD

📚 Sample References

PMID 31201582

Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells

Cell Biol Toxicol · 2020

PMID 31912839

Luteolin reduces fat storage in Caenorhabditis elegans by promoting the central serotonin pathway

Food Funct · 2020

PMID 31976547

Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties

Br J Pharmacol · 2020

⚗️ All Ingredient data fields for Luteolin

⚗️ Identity

Name

Luteolin

Aliases / Synonyms

491-70-3; 3',4',5,7-Tetrahydroxyflavone; Digitoflavone; Luteolol; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Flacitran; Luteoline; Salifazide; Weld Lake

🧪 Chemistry

Molecular Weight

286.2390

LogP

2.2824

Drug-likeness

0.511

Oral Bioavailability

36.1630

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

Isomeric SMILES

C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

InChIKey

IQPNAANSBPBGFQ-UHFFFAOYSA-N

InChI

InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

🔗 External References

HERB DB

HBIN033803 ↗

PubChem CID

5280445 ↗

CAS Number

491-70-3 ↗

NPASS

NPC279121

HIT

C0199

SymMap

TCMID

13130

TCMSP

MOL000006

TCM-ID

2858

🔍 Raw view — every non-empty column on this row (36 fields)

name

Luteolin

common names

491-70-3; 3',4',5,7-Tetrahydroxyflavone; Digitoflavone; Luteolol; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Flacitran; Luteoline; Salifazide; Weld Lake

herb ingredient id

HBIN033803

canonical smiles

C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

isomeric smiles

C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

inchi

InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

inchikey

IQPNAANSBPBGFQ-UHFFFAOYSA-N

mol wt

286.2390

num h acceptors

num h donors

mol logp

2.2824

num rotatable bonds

drug likeness

0.511

ob score

36.1630

cas id

491-70-3

symmap mol id

tcmid ingredient id

13130

tcmsp ingredient id

MOL000006

tcm id ingredient id

2858

pubchem cid

5280445

npass id

NPC279121

hit id

C0199

tcmsp mol id

MOL000006

tcmsp molecule id

🌿 Related Herbs

1 · contains this compound

Ephedra

Ma Huang

🧬 Gene / Protein Targets

30 · directly binds these targets

Gene AR

CD40LG

Gene CD40LG

EGFR

Gene EGFR

HMOX1

Gene HMOX1

ICAM1

Gene ICAM1

IFNG

Gene IFNG

INSR

Gene INSR

PCNA

Gene PCNA

MAPK1

Gene MAPK1

TNF

Gene TNF

TYR

Gene TYR

VEGFA

Gene VEGFA

PTGES

Gene PTGES

NCOA2

Gene NCOA2

Prostaglandin G/H synthase 1

Prostaglandin G/H synthase 2

Heat shock protein HSP 90

Dipeptidyl peptidase IV

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform

Trypsin-1

mRNA of PKA Catalytic Subunit C-alpha

Transcription factor p65

RAC-alpha serine/threonine-protein kinase

Transcription factor AP-1

Caspase-3

Xanthine dehydrogenase/oxidase

Interstitial collagenase

Peroxisome proliferator-activated receptor gamma

Glutathione S-transferase P

Solute carrier family 2, facilitated glucose transporter member 4

🏥 Linked Health Topics

30 · diseases via target pathways

Hypospadias 1, X-Linked

syndrome

Prostate cancer

disease

Spinal and bulbar muscular atrophy

disease

XY disorders of sex development (Other)

disease

XY disorders of sex development (Disorders in androgen synthesis or action)

disease

Spinal and bulbar muscular atrophy of Kennedy

disease

Androgen insensitivity

disease

Squamous Cell Carcinoma

disease

Lymphangiomatosis

syndrome

Glioblastoma Multiforme

Non-small Cell Lung Cancer

Psoriasis and Psoriatic Disorders

disease

Diabetes Mellitus

group

Proliferative diseases

disease

Neurodegenerative diseases

Congestive Heart Failure

syndrome

Hyperimmunoglobulinemia D

syndrome

Periodic Fever Syndrome

syndrome

📋 Clinical Trials

3 · subject of clinical study

NCT03444558 Effects of Natural Supplement Containing Chlorogenic Acid and Luteolin on Cardio

→ Metabolic Syndrome

NCT01847521 Effects of the Anti-inflammatory Flavonoid Luteolin on Behavior in Children With

→ Autism Spectrum Disorders

NCT05204407 Luteolin for the Treatment of People With Schizophrenia

→ Schizophrenia|Schizoaffective Disorder

📊 Meta-Analyses

2 · systematic review

CRD42021226773 Cardioprotective effects and Possible mechanisms of Luteolin for Myocardial isch

CRD42023490581 Efficacy of antioxidant-based pharmacological therapies in Autism Spectrum Disor

→ Symptom management in patients with ASD

📚 PubMed References

12 · cited research

PMID 31201582 Luteolin modulates gene expression related to steroidogenesis, apoptosis, and st

Cell Biol Toxicol

PMID 31912839 Luteolin reduces fat storage in Caenorhabditis elegans by promoting the central

Food Funct

PMID 31976547 Luteolin prevents irinotecan-induced intestinal mucositis in mice through antiox

Br J Pharmacol

PMID 31994822 Luteolin suppresses bladder cancer growth via regulation of mechanistic target o

Cancer Sci

PMID 32035215 Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Ak

Food Chem Toxicol

PMID 32038239 Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in

Front Pharmacol

PMID 32256362 Luteolin Attenuates Allergic Nasal Inflammation via Inhibition of Interleukin-4

Front Pharmacol

PMID 32503896 Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeuti

J Am Soc Nephrol

PMID 32783997 Luteolin ameliorates experimental colitis in mice through ERK-mediated suppressi

Food Chem Toxicol

PMID 32903480 The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the

Front Pharmacol

PMID 33050842 The effect of hesperidin and luteolin isolated from Eriocephalus africanus on ap

J Biomol Struct Dyn

PMID 33352494 Luteolin suppresses androgen receptor-positive triple-negative breast cancer cel

Phytomedicine

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables