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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Glycyrrhetinic acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Glycyrrhetinic acid

Immune Thrombocytopenia 1

📋 Sample Trials

NCT03998982

Glycyrrhetinic Acid Combined With Dexamethasone in Management of Newly Diagnosed ITP

Unknown · Phase 4

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 30976491

Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins

Acta Pharm Sin B · 2019

PMID 28933787

Blocking autophagy enhances the apoptotic effect of 18β-glycyrrhetinic acid on human sarcoma cells via endoplasmic reticulum stress and JNK activation

Cell Death Dis · 2017

PMID 31830590

Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by modulating antiangiogenic and proapoptotic pathways in vitro and in vivo

J Nutr Biochem · 2020

⚗️ All Ingredient data fields for Glycyrrhetinic acid

⚗️ Identity

Name

Glycyrrhetinic acid

Aliases / Synonyms

enoxolone; 471-53-4; Glycyrrhetic acid; Uralenic acid; 18-beta-Glycyrrhetinic acid; 18beta-Glycyrrhetinic acid; Rhetinic Acid; Glycyrrhetin; Biosone

🧪 Chemistry

Molecular Weight

470.6940

LogP

6.4126

Drug-likeness

0.464

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C

Isomeric SMILES

C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O

InChIKey

MPDGHEJMBKOTSU-YKLVYJNSSA-N

InChI

InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1

🔗 External References

HERB DB

HBIN028184 ↗

PubChem CID

10114 ↗

CAS Number

471-53-4 ↗

NPASS

NPC93503

TCMID

23291; 8840

TCM-ID

3939

🔍 Raw view — every non-empty column on this row (30 fields)

name

Glycyrrhetinic acid

common names

enoxolone; 471-53-4; Glycyrrhetic acid; Uralenic acid; 18-beta-Glycyrrhetinic acid; 18beta-Glycyrrhetinic acid; Rhetinic Acid; Glycyrrhetin; Biosone

herb ingredient id

HBIN028184

canonical smiles

CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C

isomeric smiles

C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O

inchi

inchikey

MPDGHEJMBKOTSU-YKLVYJNSSA-N

mol wt

470.6940

num h acceptors

num h donors

mol logp

6.4126

num rotatable bonds

drug likeness

0.464

cas id

471-53-4

tcmid ingredient id

23291; 8840

tcm id ingredient id

3939

pubchem cid

10114

npass id

NPC93503

📋 Clinical Trials

1 · subject of clinical study

NCT03998982 Glycyrrhetinic Acid Combined With Dexamethasone in Management of Newly Diagnosed

→ Immune Thrombocytopenia

📚 PubMed References

8 · cited research

PMID 30976491 Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the

Acta Pharm Sin B

PMID 28933787 Blocking autophagy enhances the apoptotic effect of 18β-glycyrrhetinic acid on h

Cell Death Dis

PMID 31830590 Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by

J Nutr Biochem

PMID 34630081 Glycyrrhetinic Acid Protects α-Naphthylisothiocyanate- Induced Cholestasis Throu

Front Pharmacol

PMID 34775357 Glycyrrhetinic acid reverses antibiotic-induced intestinal epithelial injury thr

Phytomedicine

PMID 35712714 Hepatoprotective Effects of Glycyrrhetinic Acid on Lithocholic Acid-Induced Chol

Front Pharmacol

PMID 35967372 Glycyrrhetinic acid regulates impaired macrophage autophagic flux in the treatme

Front Immunol

PMID 36070662 Natural compound glycyrrhetinic acid protects against doxorubicin-induced cardio

Phytomedicine

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables