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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Cepharanthine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Cepharanthine

Asymptomatic COVID-19 1

📋 Sample Trials

NCT05398705

Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitalized Adults With COVID-19

Completed · Phase 2

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 31699152

Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network

J Exp Clin Cancer Res · 2019

PMID 29024815

Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer

Cancer Lett · 2018

PMID 28923401

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth

Cancer Lett · 2017

⚗️ All Ingredient data fields for Cepharanthine

⚗️ Identity

Name

Cepharanthine

Aliases / Synonyms

481-49-2; Cepharanthin; (+)-Cepharanthine; O-Methylcepharanoline; Cepharantin; Cepharanthine [JAN]; CCRIS 6539; 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; Cepharanthine (TN)

🧪 Chemistry

Molecular Weight

606.7190

LogP

6.8739

Drug-likeness

0.245

Oral Bioavailability

77.4180

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3

Isomeric SMILES

CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3

InChIKey

YVPXVXANRNDGTA-WDYNHAJCSA-N

InChI

InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1

🔗 External References

HERB DB

HBIN020124 ↗

PubChem CID

10206 ↗

CAS Number

481-49-2 ↗

NPASS

NPC73492

SymMap

671

TCMID

3412

TCMSP

MOL006973

TCM-ID

5813

🔍 Raw view — every non-empty column on this row (33 fields)

name

Cepharanthine

common names

481-49-2; Cepharanthin; (+)-Cepharanthine; O-Methylcepharanoline; Cepharantin; Cepharanthine [JAN]; CCRIS 6539; 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; Cepharanthine (TN)

herb ingredient id

HBIN020124

canonical smiles

CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3

isomeric smiles

CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3

inchi

inchikey

YVPXVXANRNDGTA-WDYNHAJCSA-N

mol wt

606.7190

num h acceptors

num h donors

mol logp

6.8739

num rotatable bonds

drug likeness

0.245

ob score

77.4180

cas id

481-49-2

symmap mol id

671

tcmid ingredient id

3412

tcmsp ingredient id

MOL006973

tcm id ingredient id

5813

pubchem cid

10206

npass id

NPC73492

📋 Clinical Trials

1 · subject of clinical study

NCT05398705 Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitali

→ Asymptomatic COVID-19

📚 PubMed References

7 · cited research

PMID 31699152 Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosom

J Exp Clin Cancer Res

PMID 29024815 Identification of a novel autophagic inhibitor cepharanthine to enhance the anti

Cancer Lett

PMID 28923401 Pharmacological blockade of cholesterol trafficking by cepharanthine in endothel

Cancer Lett

PMID 21628669 Genetic variants of ABCC10, a novel tenofovir transporter, are associated with k

J Infect Dis

PMID 34956164 Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Dow

Front Microbiol

PMID 35186185 Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mic

Oxid Med Cell Longev

PMID 35800437 Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regul

Front Pharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables