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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
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Herb
6,826
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Ingredient
44,598
→
🧬
Gene Target
15,695
→
🏥
Disease
30,467
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
🏥 Disease / Health Topic
Renal Insufficiency
15
Clinical Trials
6
Meta-Analyses
0
PubMed References
📋 Sample Trials
NCT00185783
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
Completed
NCT00915343
Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency
Completed · Phase 2|Phase 3
NCT01450930
Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency
Completed · Phase 2
📊 Sample Meta-Analyses
CRD42018108509
The metabolic effects of once daily modified release hydrocortisone vs standard glucocorticoid replacement in the treatment of adults with adrenal insufficiency
Adrenal insufficiency is an endocrinopathy resulting from dysfunction of cortiso
CRD42021225621
Efficacy and safety of prednisolone vs hydrocortisone in the management of hypocortisolism: A meta-analysis
Glucocorticoid replacement is the primary treatment of hypocortisolism, which ma
CRD42021253990
Protective effect of mannitol on cisplatin-induced nephrotoxicity：a systematic review and meta-analysis
Cisplatin is a basic and widely used chemotherapeutic agent used in the treatmen
📚 Sample References
None linked yet.
🏥 All Disease / Health Topic data fields for Renal Insufficiency
🏥 Names
Disease Name
Renal Insufficiency
Alias Names
Renal Failure; Renal Insufficiency; Kidney Failure
Topic Type
syndrome
🧬 Ontology Classifications
DisGeNET Type
disease
UMLS Type
Disease or Syndrome
MeSH Class
Male Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications
HPO Class
Abnormality of the genitourinary system
DO Class
disease of anatomical entity
🔗 External References
🔍 Raw view — every non-empty column on this row (29 fields)
name
Renal Insufficiency
alias name
Renal Failure; Renal Insufficiency; Kidney Failure
topic type
syndrome
disgenet disease type
disease
umls disease type
Disease or Syndrome
mesh disease class
Male Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications
hpo disease class
Abnormality of the genitourinary system
do disease class
disease of anatomical entity
umls disease type id
T047
mesh disease class id
C12; C13
hpo disease class id
HP:0000119
do disease class id
DOID:7
herb disease id
HBDIS014591
disgenet id
C1565489
mesh id
D051437
hpo id
HP:0000083
do id
1074
⚗️ Related Ingredients
2 · compounds in this herb📋 Clinical Trials
12 · subject of clinical studyNCT00185783 Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in P
→ Sepsis|Relative Adrenal Insufficiency
NCT00915343 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insuffi
→ Adrenal Insufficiency
NCT01450930 Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic
→ Primary Adrenal Insufficiency
NCT01546922 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUP
→ Adrenal Insufficiency
NCT01960530 An Investigational Study of Hydrocortisone
→ Adrenal Insufficiency
NCT03019614 An Open Label Study in Healthy Volunteers to Compare Chronocort® to Hydrocortiso
→ Congenital Adrenal Hyperplasia|Adrenal Insufficien
NCT04621565 Hydrocortisone Use During Peri-operation for Pituitary Adenomas
→ Pituitary Adenoma|Adrenal Insufficiency|Surgery
NCT02433925 Resveratrol's Effects on Inflammation and Oxidative Stress in Chronic Kidney Dis
→ Chronic Renal Insufficiency
NCT01093261 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Bra
→ Traumatic Brain Injury|Trauma|Adrenal Insufficienc
NCT01859312 Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyper
→ Adrenal Insufficiency|Excess Androgen|Congenital A
NCT01265966 Cortisol Response to Moderate and Deep Sedation in Children
→ Adrenal Insufficiency
NCT03013166 THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insuffic
→ Adrenal Insufficiency
📊 Meta-Analyses
6 · systematic reviewCRD42018108509 The metabolic effects of once daily modified release hydrocortisone vs standard
→ Adrenal insufficiency is an endocrinopathy resulti
CRD42021225621 Efficacy and safety of prednisolone vs hydrocortisone in the management of hypoc
→ Glucocorticoid replacement is the primary treatmen
CRD42021253990 Protective effect of mannitol on cisplatin-induced nephrotoxicity：a syste
→ Cisplatin is a basic and widely used chemotherapeu
CRD42020191148 Prevention of preeclampsia with heparin in high-risk pregnant women: a systemati
→ Pre-eclampsia (defined as the presence of high blo
CRD42021254921 Dietary sodium restriction in the management of chronic kidney disease : A meta-
→ Chronic Kidney Disease, renal disease, renal insuf
CRD42023470809 Clinical, Metabolic, and Bone Effects and Safety of Modified-Release Hydrocortis
→ Adrenal insufficiency
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables