Trans-resveratrol · AlternativeMed

⚗️ Identity

Name

Trans-resveratrol

Aliases / Synonyms

resveratrol; 501-36-0; 3,4',5-Trihydroxystilbene; (E)-5-(4-Hydroxystyryl)benzene-1,3-diol; 3,5,4'-Trihydroxystilbene; (E)-resveratrol; Resvida; 3,4',5-Stilbenetriol; 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol

🧪 Chemistry

Molecular Weight

228.2470

LogP

2.9738

Drug-likeness

0.692

H-Bond Acceptors

3

H-Bond Donors

3

Rotatable Bonds

2

🔗 External References

HERB DB

HBIN046831 ↗

PubChem CID

445154 ↗

DrugBank

DB02709 ↗

InChIKey

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

95

Clinical Trials

84

Meta-Analyses

131

PubMed References

Top Conditions Studied with Trans-resveratrol

Healthy 5 Impaired Glucose Tolerance 2 Endothelial Dysfunction 2 Healthy, no Evidence of Disease 2 Pre-diabetes 2 Alzheimer's Disease 2 Friedreich Ataxia 2 Type 2 diabetes mellitus is a metabolic disease characterize 1 Obesity is a chronic disease that causes important changes i 1 Type 2 Diabetes 1 Infertility 1 Cognitive and Cerebral Blood Flow Effects of Resveratrol 1

📋 Sample Trials

NCT03090997

Effect of Resveratrol and Vitamin C on Insulin Resistance Among Postmenopausal Women

Unknown · Postmenopausal|Insulin Resistance

NCT04867252

Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome

Completed · Phase 2 · PCOS

NCT01324089

Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol

Completed · Focus of the Study: Normal Volunteers

NCT00098969

UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants

Completed · Phase 1 · Unspecified Adult Solid Tumor, Protocol

NCT00256334

Resveratrol for Patients With Colon Cancer

Completed · Phase 1 · Colon Cancer|Cancer

NCT00433576

Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery

Completed · Phase 1 · Adenocarcinoma of the Colon|Adenocarcino

📊 Sample Meta-Analyses

CRD42021293495

Resveratrol and curcumin for Chagas Disease treatment. A Systematic Review

CRD42021266048

Effect and mechanisms of resveratrol in animal models of ischemic stroke: a systematic review and meta-analysis

CRD42022353317

Neuroprotective Effect and Possible Mechanisms of Resveratrol in Diabetes-Related Cognitive Impairment: A Systematic Review and Meta-Analysis of Animal Studies

CRD42013003652

Effects of resveratrol on human health: a meta-analysis of clinical trials

All clinical trials.

CRD42014012844

Tissue distribution of resveratrol

There is no specific condition being studied, but rather the tissue distribution

CRD42014014431

Effects of resveratrol on some risk for developing type 2 diabetes: A systematic review and meta-analysis on controlled clinical trials

Although resveratrol has been widely studied for its potential health benefits,

📚 Sample References

PMID 31189495

Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system

Clin Nutr · 2020

PMID 31294462

Resveratrol and HIV-protease inhibitors control UCP1 expression through opposite effects on p38 MAPK phosphorylation in human adipocytes

J Cell Physiol · 2020

PMID 31331257

Differential inhibitory effects of resveratrol on excitotoxicity and synaptic plasticity: involvement of NMDA receptor subtypes

Nutr Neurosci · 2021

PMID 31664166

Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma

Cancer Gene Ther · 2020

PMID 31667715

Resveratrol Activates Neuronal Autophagy Through AMPK in the Ischemic Brain

Mol Neurobiol · 2020

PMID 31704236

Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB

Biochem Pharmacol · 2020

🏥 Linked Health Topics 12 · matched via study conditions

Amyotrophic Lateral Sclerosis