natural remedies · Ingredient
Pregnenolone
Formula: C21H32O2 · MW: 316.4850000000001 · Drug-likeness: 0.722
⚗️ Identity
Name
Pregnenolone
Aliases / Synonyms
145-13-1; 3beta-Hydroxypregn-5-en-20-one; Arthenolone; Pregnetan; Pregneton; Pregnolon; Prenolon; Regnosone; Skinostelon
🧪 Chemistry
Molecular Weight
316.4850
LogP
4.5153
Drug-likeness
0.722
H-Bond Acceptors
2
H-Bond Donors
1
Rotatable Bonds
1
🔗 External References
19
Clinical Trials
2
Meta-Analyses
7
PubMed References
Top Conditions Studied with Pregnenolone
Schizophrenia 3
Schizophrenia|Schizoaffective Disorder 2
Healthy 2
Stress Disorders, Post-Traumatic 1
Autism Spectrum Disorder|Autism 1
Schizophrenia|Schizophreniform Disorder|Schizoaffective Diso 1
Alcohol Use Disorder 1
Perceived Social Isolation 1
Marijuana Dependence 1
Major Depressive Disorder 1
Schizophrenia, schizoaffective disorer or other psychotic di 1
As a chronic psychiatric disorder, schizophrenia affects the 1
📋 Sample Trials
NCT00174889
Pregnenolone in the Management of Schizophrenia Patients
Completed · Phase 1 · Schizophrenia
NCT00560781
Targeting Cognition in PTSD: Pregnenolone Augmentation of SSRIs
Completed · Stress Disorders, Post-Traumatic
NCT00560937
Pilot Study of Pregnenolone Augmentation Targeting Cognitive Symptoms in Persistently Symptomatic Patients With Schizophrenia
Completed · Schizophrenia
NCT00615511
Efficacy of Pregnenolone in Patients With Schizophrenia
Completed · Phase 2 · Schizophrenia|Schizoaffective Disorder
NCT00623506
Adjunctive Pregnenolone in Veterans With Mild TBI
Completed · Traumatic Brain Injury
NCT00728728
Pregnenolone for Cognitive and Negative Symptoms in Schizophrenia
Completed · Phase 2 · Schizophrenia|Schizoaffective Disorder
📊 Sample Meta-Analyses
CRD42017081355
Adjunctive pregnenolone therapy for the treatment of schizophrenia and other psychotic disorders
Schizophrenia, schizoaffective disorer or other psychotic disorder.
CRD42021233396
Adjunctive pregnenolone for schizophrenia: a meta-analysis of randomized controlled trials
As a chronic psychiatric disorder, schizophrenia affects the worldwide populatio
📚 Sample References
PMID 24385629
Pregnenolone can protect the brain from cannabis intoxication
Science · 2014
PMID 28220044
Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice
Mol Psychiatry · 2017
PMID 30853321
Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries
J Mol Cell Cardiol · 2019
PMID 25781227
Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway
Transl Psychiatry · 2015
PMID 23955365
Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration
Nat Chem Biol · 2013
PMID 21108630
Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids
Br J Pharmacol · 2011
🏥 Linked Health Topics 6 · matched via study conditions