natural remedies · Ingredient
Luteolin
Formula: C15H10O6 · MW: 286.239 · Drug-likeness: 0.511
⚗️ Identity
Name
Luteolin
Aliases / Synonyms
491-70-3; 3',4',5,7-Tetrahydroxyflavone; Digitoflavone; Luteolol; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Flacitran; Luteoline; Salifazide; Weld Lake
🧪 Chemistry
Molecular Weight
286.2390
LogP
2.2824
Drug-likeness
0.511
Oral Bioavailability
36.1630
H-Bond Acceptors
6
H-Bond Donors
4
Rotatable Bonds
1
🔗 External References
3
Clinical Trials
2
Meta-Analyses
40
PubMed References
Top Conditions Studied with Luteolin
📋 Sample Trials
NCT03444558
Effects of Natural Supplement Containing Chlorogenic Acid and Luteolin on Cardio-metabolic Risk Factors
Completed · Metabolic Syndrome
NCT01847521
Effects of the Anti-inflammatory Flavonoid Luteolin on Behavior in Children With Autism Spectrum Disorders
Completed · Phase 2 · Autism Spectrum Disorders
NCT05204407
Luteolin for the Treatment of People With Schizophrenia
Recruiting · Schizophrenia|Schizoaffective Disorder
📊 Sample Meta-Analyses
CRD42021226773
Cardioprotective effects and Possible mechanisms of Luteolin for Myocardial ischemia-reperfusion injury: A Systematic Review and Meta-analysis
CRD42023490581
Efficacy of antioxidant-based pharmacological therapies in Autism Spectrum Disorder: A Systematic Review
Symptom management in patients with ASD
📚 Sample References
PMID 31201582
Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells
Cell Biol Toxicol · 2020
PMID 31912839
Luteolin reduces fat storage in Caenorhabditis elegans by promoting the central serotonin pathway
Food Funct · 2020
PMID 31976547
Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties
Br J Pharmacol · 2020
PMID 31994822
Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway
Cancer Sci · 2020
PMID 32035215
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats
Food Chem Toxicol · 2020
PMID 32038239
Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage
Front Pharmacol · 2020
🏥 Linked Health Topics 1 · matched via study conditions
🔗 Knowledge Graph Connections
Open full graph →Real research connections from HERB 2.0, TCMSP, and clinical evidence sources. 25 related entities shown — click any to follow the trail.
🌿 Herbs containing this compound · 1
🧬 Gene targets · 12
Prostaglandin G/H synthase 2
binding 0.861
Heat shock protein HSP 90
binding 0.847
Trypsin-1
binding 0.830
NCOA2
NCOA2
binding 0.828
mRNA of PKA Catalytic Subunit C-alpha
binding 0.817
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform
binding 0.813
AR
AR
binding 0.804
Prostaglandin G/H synthase 1
binding 0.775
Dipeptidyl peptidase IV
binding 0.771
72 kDa type IV collagenase
Adenylate cyclase type 2
Amyloid beta A4 protein
🏥 Linked health topics · 12
Abdominal aortic aneurysm
disease
Adenomatous polyposis
disease
Allergic airway inflammation
disease
Alzheimer'S Disease
syndrome
Analgesics
disease
Androgen insensitivity
disease
Angioedema
phenotype
Arthritis
syndrome
Asthma
syndrome
Autoimmune Diseases
group
Behcet's disease
disease
Bladder cancer
disease